Monday, April 26, 2010

Cholesterol - What's In a Number?

We all hear about cholesterol and how it increases our risk of heart disease.  Most everyone either knows someone who is on a cholesterol lowering medication, or is on one themselves.  We are left to believe that high cholesterol is just an inevitable thing, or that it is genetic.  But the truth is that it doesn't have to be inevitable.  Unfortunately we are, to some degree, set up to fail.  Even those who want to lower their cholesterol by following the national guidelines are failing.  This is due to the fact that these guidelines are not based on the research.  If you take a closer look, you'll find that following the current guidelines will not help one achieve their goal.  So what will?  Keep reading, bear with me, and I'll let you know.

First we need to understand what cholesterol is.  Cholesterol is made by all animals and is not essential to obtain in the diet.  In fact the body makes cholesterol on it's own.  The purpose of cholesterol - it's an essential component of all sex hormones and the membrane that surrounds our cells.  Since we don't need more than the body can make, excess consumption actually leads to a build up of cholesterol in our bodies, which later accumulates in our blood vessels.  It isn't just cholesterol consumption that increases blood serum cholesterol levels.  Eating excess amounts of dietary fat actually increases the body's production of cholesterol as well.   This is why a vegetarian who eats oil, dairy, and processed foods like cookies, chips, doughnuts, pastries, etc. can still have a high total cholesterol level. 

LDL cholesterol (low density lipoprotein) is nasty stuff.  Just remember the first "L" in LDL stands for LETHAL.  LDL cholesterol is the stuff that, in excess, creates deposits in the vessels causing a build-up along the walls of the arteries that create a narrowing, and possibly an eventual complete blockage of the artery opening, causing the blood flow to significantly decrease through the vessel.  

One would think that the most common cause of a heart attack is the complete blockage of an artery.  In fact, more often the case is that a small, fatty piece of plaque ruptures or breaks off from the artery wall and travels through the blood stream to another location where it gets stuck and causes a blockage.  This could occur in the brain, a lung or coronary artery.  Scary stuff, no?

The current guidelines found on the American Heart Association's website are as follows:
Total cholesterol:  Less than 200 mg/dl
LDL: optimal is less than 100mg/dl, 100-129 mg/dl is considered "near optimal"

Now, if you look at medical research, the appropriate numbers seem a lot different than those listed above. For example, it's been known in the medical community for decades that 1 in 4 heart attacks occur in those with a total cholesterol level between 180-210 mg/dl.  The Framingham Study is a 50 year (and counting)  multi-generational heart study that revealed 1/3 of those with heart disease, participating in the study, had a total cholesterol of 150-200 mg/dl.

The Framingham Heart Study also found among their subjects that NO ONE WITH A HEART ATTACK EVER HAD A TOTAL CHOLESTEROL VALUE UNDER 150mg/dlThat's huge!  Another study known simply as "The China Study", and considered to be one of the most comprehensive nutrition studies ever, discovered that residents of rural China (where heart disease is nearly non-existent) had total cholesterol levels that ranged from 90-150 mg/dl
So, you see, millions of Americans who are doing their best to follow the guidelines to decrease their risk for heart disease are getting sick, despite their best efforts, simply because they don't have accurate, complete information. Argh!! I get so worked up over this!

This is only a sampling of the research that can allow us to come to the following conclusion...
If we REALLY want to avoid heart disease, we need to get our total cholesterol levels below 150 mg/dl, LDL below 80 mg/dl, and decrease our fat intake. The most appropriate and effective way to achieve this goal, with or without cholesterol lowering medication, is to significantly increase our intake of high fiber vegetables, fruits, legume and whole grains and limit our intake of animal products.
 
So there you have it: the national guidelines and what the research tells us about the reality of avoiding heart disease.  If you are interested in learning more about this topic, I highly recommend reading Prevent and Reverse Heart Disease by Dr. Caldwell Esselstyn, Jr., The China Study by T. Colin Campbell, and Dr. Dean Ornish's Program for Reversing Heart Disease
 
Now that you have the information, you have the power to make your own educated decision about your cholesterol.  If you haven't had it checked recently, ask your doctor for a fasting blood serum cholesterol test.  You can also call your local pharmacy about cholesterol testing.  Some blood banks also offer to send your blood cholesterol results when you donate a pint of blood too.  
 
A great place to start is to try the recipe posted for Everyday Oatmeal - a great, cholesterol lowering way to start your day!  
 
In good health,
Your Nutritionista

4 comments:

  1. Thank you, Melissa, for discussing a very interesting topic! I hope you don’t mind me writing a long comment, but I find this topic fascinating. As you described, there is no doubt that wherever the western diet travels, chronic diseases and mortality from these diseases follows. Recently, it looks as though scientific consensus on the dietary culprit(s) has been in flux. Like you I think dietary intervention and not statins are the best solution for most people and you highlighted some effective dietary changes that can lower disease risk factors. But perhaps there is another dietary villain hiding in most of our foods.

    The original studies you highlight established a correlation between dietary factors including dietary cholesterol and saturated fat and heart disease. The surprises came when the results from prospective studies, which were needed to establish causation, did not show consistent support for the diet/heart hypothesis. The role of dietary cholesterol came into question a while back in many of the well known egg studies that showed increasing dietary cholesterol was not sufficient to increase blood cholesterol levels in most people outside of cholesterol hyperresponders.
    http://www.ncbi.nlm.nih.gov/pubmed/19751443

    Saturated fat was also considered to be a major contributor to disease and mortality. The Seven Countries Study showed a somewhat linear correlation between saturated fat consumption and heart disease, but many prospective studies have failed to show a causative link between saturated fat and disease.
    http://www.ncbi.nlm.nih.gov/pubmed/20354806

    While both saturated fat and dietary cholesterol may still contribute significantly to disease, there must be another player that makes them deadly. One interesting thing about many of the countries in the Seven Countries Study was the correlation between saturated fat and sugar consumption, but this apparently was not considered by Ancel Keys in the study. Recently sugar has been taking a beating in the scientific literature. In addition to its causative role in a wide variety of diseases, sugar negatively impacts blood cholesterol levels.
    http://www.ncbi.nlm.nih.gov/pubmed/20407058

    There is a great video by Dr. Robert Lustig from the UCSF Department of Medicine on sugar. It is long but informative and describes the causative role of dietary fructose from table sugar and high fructose corn syrup in a variety of diseases. http://www.uctv.tv/search-details.aspx?showID=16717

    There must be a perfect storm caused by a high sugar and high fat diet. What about a diet high in fat and cholesterol but not sugar? That experiment is going on now with the low carb folks. While I am no fan of low carb diets, they are providing some surprising results at least in their hypocaloric phase before carbs and sugar are reintroduced. Does this mean that a diet should either be plant based or animal based but not both, or is there a middle ground where, in the absence of sugar, the two can coexist?

    So to your list of dietary offenders I would like to add sugar, which seems to light the fuse on the chronic disease bomb.

    Thanks again, Melissa!

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  2. Chris, thank you so much for your well thought out and cited comments.

    There are many things that play into the increase in the many "diseases of affluence" (aka heart disease, type 2 diabetes, various cancers etc.)in our society today. And your comment only highlights this, along with why so many people today are so confused. It seems that for every article that states one claim, the next week there is another study that contradicts the findings of the former.

    I completely understand and agree with your concern about dietary sugar. High fructose corn syrup has been a subject of serious debate as of late. Added sugars contribute added calories with little to no added nutritional value. And the last thing most of us need is more calories! High fructose corn syrup (HFCS) is roughly 1/2 fructose and 1/2 glucose, just like table sugar. And few differences have been found between the impact of HFCS and table sugar on various health factors. So I guess the bottom line there is to just try to avoid added sugars all together.
    http://www.ncbi.nlm.nih.gov/pubmed/19064539
    http://www.ncbi.nlm.nih.gov/pubmed/18469239

    As for dietary cholesterol, I too can point to research reviews and meta-analyses that state that dietary cholesterol and saturated fat do in fact impact LDL levels. However, I think that a much more important thing to keep in mind is this. Researchers often seem very focused on looking at how a single factor influences the outcome of something else (ie: the cholesterol in eggs and it's effect on blood cholesterol). What we forget is that you can't eat the egg without all of the other chemical compounds and dietary nutrients that are also being consumed at the same time, which may also have an effect on cholesterol (i.e. saturated fat and animal protein). One review indicated that, when these "dietary confounders" were considered (which was quite rarely done in published studies), it was found that eating 1 egg a day did not negatively impact cholesterol levels. I find this conclusion very interesting since the the amount of cholesterol in 1 egg is 213 mg. and the American Heart Association recommends eating less than 300mg of cholesterol per day. So, if that one egg is the only thing you consume all day with any cholesterol (and remember animal products contain cholesterol), then I can see how 1 egg/day would not have a tremendous impact.
    http://www.ncbi.nlm.nih.gov/pubmed/11023006

    With regard to the impact of saturated fat on cholesterol, I think the bottom line is again, taking a more inclusive and holistic approach. It's the whole enchilada that's going to positively impact serum cholesterol. By this, I mean decreasing saturated fat, cholesterol and animal protein intake and increasing soluble fiber intake in the form of more fruits, vegetables, whole grains and legumes.
    http://www.ncbi.nlm.nih.gov/pubmed/18047254

    I'm so glad you brought up the issue of decreased cholesterol in those who go on a low carb, Atkins-type diet, because I know others may have wondered about that as well. The reason people do so well, losing weight and decreasing their cholesterol initially is because they are significantly restricting caloric intake. Anytime you restrict caloric intake to under 1450 Cal/day, you're going to have these kinds of results, initially, but the fact is, a diet like this is very difficult to maintain. I have yet to see any long-term studies that have concluded that this type of diet can maintain healthy cholesterol levels.

    The other concern I have about high protein diets, besides the high intake of cholesterol and saturated fat, is the lack of plant foods that are high in soluable fiber, phytochemicals and other nutrtients that are necessary for cancer/disease prevention and overal good health.

    Thank you again Chris for your stimulating and thoughtful comments. Consider sugar on the list of offenders. I'll even do a post related to sugar, in honor of you Chris, in the coming weeks. :)

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  3. Thanks, Melissa, for your response and for the links. They are very interesting. Again I apologize for writing so much and know that you are aware of most of this information but I hope it is good for discussion and possibly ideas for future posts.

    It looks as though we agree considerably and no doubt there is a lot still to be worked out in the field. I agree that confounding factors determine the extent to which dietary cholesterol and saturated fats affect blood cholesterol and most importantly how they impact health. I also agree that total cholesterol can be predictive of CVD and plant-based diets have shown success lowering total cholesterol, but researchers have been trying to determine why some individuals with fairly low total cholesterol die from cardiovascular events while others with much higher cholesterol do not. This is why the safe haven total cholesterol bar is so low, as you point out in your post.

    As an alternative to lowering cholesterol to this low level, perhaps it is just as important to focus on preventing the/a major cause of atherosclerosis, namely the formation of oxidized lipids in LDLs, specifically in vLDLs.
    http://www.ncbi.nlm.nih.gov/pubmed/19625960

    This involves preventing chronic inflammation, which results in lipid oxidation and mitochondrial damage, and minimizing vLDL particles. Interestingly, a great way to reduce vLDLs is to reduce fructose consumption (I know, fructose again) since fructose metabolism results in de novo lipogenesis in the liver resulting in vLDL production.
    http://www.ncbi.nlm.nih.gov/pubmed/19403641

    A high omega 6:3 ratio in the western diet is thought to enhance inflammation. Most vegetable oils are high in omega 6 and low in omega 3, helping to create this imbalance.
    http://www.ncbi.nlm.nih.gov/pubmed/18296320

    Additionally, these polyunsaturated fats are the ones that become oxidized in the vLDLs.
    The fact that C-reactive protein, which is a marker of inflammation, is a good predictor of cardiovascular events further supports the central role of inflammation in CVD and other health problems and offers a measure beyond blood cholesterol to establish risk.
    http://www.ncbi.nlm.nih.gov/pubmed/19369869

    A high nutrient density diet, which you recommend and offer great recipes to achieve, with few processed foods reduces inflammation considerably as you know. This is seen with the Mediterranean diet, which happens to be a low sugar, low omega 6 diet.
    http://www.ncbi.nlm.nih.gov/pubmed/19689829

    I agree with your concerns about low carb diets, but you have to admit that at least the initial results are really surprising for someone who is eating grams worth of cholesterol a day and 40%+ saturated fat. Initially it blew me away that a diet really high in cholesterol and saturated fat even in a hypocaloric phase, which means that fat, saturated fat, from the tissues is being released in high amounts into the blood to be burned as fuel, actually results in a drop in blood cholesterol and improves dyslipidemia. As I said, I agree with many of your concerns with the diet and also think that many people will develop thyroid hormone problems if carbohydrates are kept really low, but these studies still surprised me. This suggests that the hormonal/metabolic state of the body can have dramatic impacts on what happens to what we eat and that confounding dietary components like vegetable oils and sugar can be important modulators of this response that lead to disease.

    Fortunately we have your recipes and the information that you share to keep us healthy!

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  4. Thanks again for your insight and discussion. Sugars and Fats are definitely in the que for future topics. I look forward to seeing what you have to say about that as well. :)

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